COVID-19 brings a new challenge to global health, the NHS and the health of vulnerable patients. Current treatment options are limited and the development and distribution of a proven vaccine may take many months. Subsequently there is a pressing need to develop new therapies which can treat patients with COVID-19, preventing their condition worsening and reducing the risk of admission to critical care and mortality.

This is the challenge that ACCORD and partner platforms has taken on. Potential new drugs which require detailed testing to demonstrate safety and clinical benefit are selected based on expert scientific review of the emerging mechanism driving severe COVID and entered into ACCORD trials which are active in hospitals across the UK working with patients and clinical teams to generate evidence for the next generation of treatments.

Aim of the platform

ACCORD is a platform for multiple drug trials, which aims to assess several potential COVID-19 treatments at the same time. These treatments are for those hospitalised with COVID-19 and will be given on top of standard care, compared with standard care alone.

Possible potential treatments include anti-viral drugs, drugs that affect the immune system and drugs which target inflammatory molecules.

What does it involve?

ACCORD has two stages:

Stage 1: Evaluation/pilot

This initial stage will assess how well potential drugs work when added onto standard care, in small groups (10-60) of patients hospitalised with COVID‑19.

Stage 2: Confirmation

Drugs that show the most potential will be assessed in larger numbers of patients hospitalised with COVID‑19.

At each stage patients will be assessed for their suitability to be involved either the day before starting the treatment or the first day of treatment. Treatment and assessments will continue for 29 days or until they are considered well enough to leave the hospital. 

They will also be asked to return for an appointment approximately 60 days after starting their treatment, with a final follow-up after approximately 90 days.

Who is leading it?

The ACCORD steering committee is chaired by Professor Tom Wilkinson, Professor of Respiratory Medicine at the University of Southampton and Honorary NHS Consultant Physician at University Hospital Southampton, and includes a team of clinical and scientific experts, representatives of the trial sponsor and the UKRI, and representatives from the trial sites and delivery group.


See full steering committee


© 2020 University Hospital Southampton